Investigation of the natural bacteriocin nisin and bioengineered nisin derivatives for the prevention and control of Staphylococcus biofilms on medical device materials / Leanne Kearney
By: Kearney, Leanne [author.].
Material type:
BookSeries: M.Sc. - Biological Sciences.Publisher: Cork : Cork Institute of Technology, 2016Description: ix, 130 pages : color diagrams, graphs ; 30 cm.Content type: text Media type: unmediated Carrier type: volumeSubject(s): Bacteriocins
| Nisin | Staphylococcal infections -- Prevention and control | Medical instruments and apparatus | Biofilms | Pathogenic bacteria | Anti-infective agentsDDC classification: THESES PRESS Dissertation note: Thesis (M.Sc.) - Cork Institute of Technolgy, 2016. Summary: "Antimicrobial resistance has evolved into being one of the major threats facing clinical environments worldwide. It has led to the decrease in effective prevention and treatment of pathogenic bacteria. One such bacterium is Staphylococcus epidermidis. Once considered a relatively harmless and commensal bacterium, it has recently evolved into being one of the leading causes of nosocomial infections. S. epidermidis has proven harmful to its ability to form detrimental biofilms. Biofilms are structured consortia of bacteria embedded in a self-producing polymer matrix that allows adherence to biotic or abiotic surfaces. These biofilms have played a leading role in healthcare-acquired infections with particular emphasis on patients with indwelling medical devices such as urinary and intravascular catheters, orthopaedic devices such as hip and knee implants. Biofilms are inherently refractory to treatment with antibiotics making them difficult to eradicate, which in turn can lead to infections, malfunction and removal of the device. Medical device-related infections are a public health concern and an economic burden, for example some European contries see 1000 deaths per year and ensuing costs of 35-164 million euros per year. This study investigated the potential of the natural antimicrobial agent called nisin - a bacterially derived antimicrobial peptide which is generally recognised as safe (GRAS) status and its bioengineered derivates (M17Q and M21A). This study examined and answered three core questions. One, nisin A prevents and controls biofilm from occuring on plastic, stainless steel, polyvinyl chloride and polyvinyl resin biomaterials. Two, the combination of nisin A and conventional antibiotics work better at preventing and treating biofilms on plastic materials and three, nisin derivatives show a positive indication that they work better than nisin A wildtype in the prevention of S. epidermidis biofilms on a range of materials. The results have demonstrated the potential benefits of including nisin as a viable option in the treatment of S. epidermidis biofilms in a clinical setting". - (Author's abstract)
| Item type | Current library | Call number | Copy number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|---|
| Reference | MTU Bishopstown Library Thesis | THESES PRESS (Browse shelf(Opens below)) | 1 | Reference | 00180101 |
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Thesis (M.Sc.) - Cork Institute of Technolgy, 2016.
Includes bibliographical references.
"Antimicrobial resistance has evolved into being one of the major threats facing clinical environments worldwide. It has led to the decrease in effective prevention and treatment of pathogenic bacteria. One such bacterium is Staphylococcus epidermidis. Once considered a relatively harmless and commensal bacterium, it has recently evolved into being one of the leading causes of nosocomial infections. S. epidermidis has proven harmful to its ability to form detrimental biofilms. Biofilms are structured consortia of bacteria embedded in a self-producing polymer matrix that allows adherence to biotic or abiotic surfaces. These biofilms have played a leading role in healthcare-acquired infections with particular emphasis on patients with indwelling medical devices such as urinary and intravascular catheters, orthopaedic devices such as hip and knee implants. Biofilms are inherently refractory to treatment with antibiotics making them difficult to eradicate, which in turn can lead to infections, malfunction and removal of the device. Medical device-related infections are a public health concern and an economic burden, for example some European contries see 1000 deaths per year and ensuing costs of 35-164 million euros per year. This study investigated the potential of the natural antimicrobial agent called nisin - a bacterially derived antimicrobial peptide which is generally recognised as safe (GRAS) status and its bioengineered derivates (M17Q and M21A). This study examined and answered three core questions. One, nisin A prevents and controls biofilm from occuring on plastic, stainless steel, polyvinyl chloride and polyvinyl resin biomaterials. Two, the combination of nisin A and conventional antibiotics work better at preventing and treating biofilms on plastic materials and three, nisin derivatives show a positive indication that they work better than nisin A wildtype in the prevention of S. epidermidis biofilms on a range of materials. The results have demonstrated the potential benefits of including nisin as a viable option in the treatment of S. epidermidis biofilms in a clinical setting". - (Author's abstract)