MARC details
| 000 -LEADER |
|---|
| fixed length control field |
03431nam a2200313 a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
2016 |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
THESES PRESS |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Kearney, Leanne, |
| Relator term |
author. |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Investigation of the natural bacteriocin nisin and bioengineered nisin derivatives for the prevention and control of Staphylococcus biofilms on medical device materials / |
| Statement of responsibility, etc. |
Leanne Kearney |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
Cork : |
| Name of producer, publisher, distributor, manufacturer |
Cork Institute of Technology, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2016. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
ix, 130 pages : |
| Other physical details |
color diagrams, graphs ; |
| Dimensions |
30 cm |
| 336 ## - CONTENT TYPE |
|---|
| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
|---|
| Media type term |
unmediated |
| Media type code |
n |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
|---|
| Carrier type term |
volume |
| Carrier type code |
nc |
| Source |
rdacarrier |
| 490 0# - SERIES STATEMENT |
|---|
| Series statement |
M.Sc. - Biological Sciences |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (M.Sc.) - Cork Institute of Technolgy, 2016. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc. note |
Includes bibliographical references. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
"Antimicrobial resistance has evolved into being one of the major threats facing clinical environments worldwide. It has led to the decrease in effective prevention and treatment of pathogenic bacteria. One such bacterium is Staphylococcus epidermidis. Once considered a relatively harmless and commensal bacterium, it has recently evolved into being one of the leading causes of nosocomial infections. S. epidermidis has proven harmful to its ability to form detrimental biofilms. Biofilms are structured consortia of bacteria embedded in a self-producing polymer matrix that allows adherence to biotic or abiotic surfaces. These biofilms have played a leading role in healthcare-acquired infections with particular emphasis on patients with indwelling medical devices such as urinary and intravascular catheters, orthopaedic devices such as hip and knee implants. Biofilms are inherently refractory to treatment with antibiotics making them difficult to eradicate, which in turn can lead to infections, malfunction and removal of the device. Medical device-related infections are a public health concern and an economic burden, for example some European contries see 1000 deaths per year and ensuing costs of 35-164 million euros per year. This study investigated the potential of the natural antimicrobial agent called nisin - a bacterially derived antimicrobial peptide which is generally recognised as safe (GRAS) status and its bioengineered derivates (M17Q and M21A). This study examined and answered three core questions. One, nisin A prevents and controls biofilm from occuring on plastic, stainless steel, polyvinyl chloride and polyvinyl resin biomaterials. Two, the combination of nisin A and conventional antibiotics work better at preventing and treating biofilms on plastic materials and three, nisin derivatives show a positive indication that they work better than nisin A wildtype in the prevention of S. epidermidis biofilms on a range of materials. The results have demonstrated the potential benefits of including nisin as a viable option in the treatment of S. epidermidis biofilms in a clinical setting". - (Author's abstract) |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Bacteriocins. |
| 9 (RLIN) |
86305 |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Nisin |
| 9 (RLIN) |
119236 |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Staphylococcal infections |
| General subdivision |
Prevention and control. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Medical instruments and apparatus. |
| 9 (RLIN) |
39718 |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Biofilms. |
| 9 (RLIN) |
110018 |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Pathogenic bacteria. |
| 9 (RLIN) |
34482 |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Anti-infective agents. |
| 9 (RLIN) |
33953 |
| 907 ## - LOCAL DATA ELEMENT G, LDG (RLIN) |
|---|
| a |
.b11211519 |
| b |
161007 |
| c |
161007 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Suppress in OPAC |
0 |
| 998 ## - LOCAL CONTROL INFORMATION (RLIN) |
|---|
| a |
c |
| Operator's initials, OID (RLIN) |
161007 |
| Cataloger's initials, CIN (RLIN) |
m |
| First Date, FD (RLIN) |
a |
| Local |
- |
| -- |
eng |
| -- |
ie |
| h |
0 |