| 000 | 02771nam a2200289 a 4500 | ||
|---|---|---|---|
| 008 | 2016 | ||
| 082 | 0 | 4 | _aTHESES PRESS |
| 100 | 1 |
_aFeeney, Audrey, _eauthor. |
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| 245 | 1 | 0 |
_aIdentification of the molecular mechanisms governing the osmotolerance of the emerging gastrointestinal pathogen Cronobacter sakazakii / _cAudrey Feeney. |
| 264 | 1 |
_aCork : _bCork Institute of Technology, _c2015. |
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| 300 |
_a156 pages : _billustrations (some color), tables ; _c30 cm |
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| 336 |
_atext _btxt _2rdacontent |
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| 337 |
_aunmediated _bn _2rdamedia |
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| 338 |
_avolume _bnc _2rdacarrier |
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| 490 | 0 | _aPh.D. - Biological Sciences | |
| 502 | _aThesis (Ph.D.) - Cork Institute of Technology, 2015. | ||
| 504 | _aBibliography: p. 140-155. | ||
| 520 | _aCronobacter sakazakii is an organism which has been associated with severe life threatening diseases in infants and neonates. Mortality rates of up to 80% have been recorded in infants infected with Cronobacter sakazakii. Infants often suffer from septicaemia, necrotising enterocolitis and meningitis as a result of infection. A characteristic feature of the opportunistic foodborne pathogen Cronobacter sakazakii is its ability to survive in extremely arid environments such as powered infant formula, making it a dangerous opportunistic pathogen of neonates. Herein, we provide a brief overview of the pathogen, clinical manifestations, environmental reservoirs and our current understanding of stress response mechanisms and virulence factors which allow it to cause disease. The work presented in this thesis represents a significant contribution to the field of C. sakazakii osmotolerence research. In 2010, when this research began, the first C. sakazkaii genome was sequenced and it marked the beginning of the elucidation of the survival of this neonatal pathogen in PIF (powdered infant formula) and the mechanisms that facilitate the survival of the organism as it navigates the varying osmolality of the infant gastrointestinal tract. While this thesis has identified and characterised the osmotolerance loci of C. sakazakii, we recognise that the story is by no means complete. The identification of multiple ProP homologues on the C. sakazakii genome is a unique feature, coupled with the structural degeneracy between these compatible solute transport systems. - (Author's abstract) | ||
| 650 | 0 |
_aEnterobacter sakazakii. _9107285 |
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| 650 | 0 |
_aPathogenic microorganisms _xAnalysis. |
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| 650 | 0 |
_aGenomics. _946112 |
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| 650 | 0 |
_aVirulence (Microbiology) _943766 |
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| 650 | 0 |
_aInfant formulas _xContamination. _9118273 |
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| 907 |
_a.b1119263x _b160421 _c160420 |
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_ac _b160420 _cm _da _e- _feng _gie _h0 |
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_c104540 _d104540 |
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