MTU Cork Library Catalogue

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A genetic switch : phage [lambda] and higher organisms / Mark Ptashne.

By: Ptashne, Mark [author].
Material type: materialTypeLabelBookPublisher: Cambridge : Cell Press Blackwell Scientific, [1992]Publisher: ©1992Edition: Second edition.Description: ix, 192 pages : illustrations (chiefly color) ; 23 cm.Content type: text Media type: unmediated Carrier type: volumeISBN: 0865422095 (paperback).Subject(s): Bacteriophage lambda | Genetic regulation | Viral geneticsDDC classification: 579.26
Contents:
Introduction -- The master elements of control -- Protein-DNA interactions and gene control -- Control circuits - setting the switch -- How do we know - the key experiments -- Eukaryotic gene regulation - an overview -- Eukaryotic gene regulation - experiments and examples.
Holdings
Item type Current library Call number Copy number Status Date due Barcode Item holds
General Lending MTU Bishopstown Library Lending 579.26 (Browse shelf(Opens below)) 1 Available 00009796
Total holds: 0

Enhanced descriptions from Syndetics:

This book is concerned with how lambda, a virus, uses its DNA to direct its growth. Biologists have long wished to know how genes are switched on and off during development and, aberrantly in diseased states.

On t.p. lambda is shown as symbol following phage.

Includes bibliographical references and index.

Introduction -- The master elements of control -- Protein-DNA interactions and gene control -- Control circuits - setting the switch -- How do we know - the key experiments -- Eukaryotic gene regulation - an overview -- Eukaryotic gene regulation - experiments and examples.

Table of contents provided by Syndetics

  • 1 The Master Elements of Control:Components of the Switch
  • The Action of Repressor and Cro
  • Induction - Flipping the Switch
  • Cooperativity - Switch Stability and Sensitivity
  • The Effect of Autoregulation
  • Other Cases
  • 2 Protein-DNA Interactions and Gene Control:The Operator
  • Repressor
  • Cro
  • Amino Acid-Base Pair Interactions
  • The Promoter
  • Gene Control
  • 3 Control Circuits - Setting the Switch:A Brief Overview of Lambda Growth
  • Control of Transcription
  • The Decision
  • Control of Integration and Excision
  • Other Phages
  • The SOS Response
  • Pathways and Cell Development
  • 4 How do we Know - The Key Experiments:The Repressor Idea
  • The Repressor Problem in the Early 1960s
  • Repressor Isolation and DNA-Binding
  • Making More Repressor
  • The Claims of Chapters One and Two
  • 5 Eukaryotic Gene Regulation - An Overview:Introduction
  • Eukaryotic Genes and their Polymerases
  • Activation
  • Repression
  • Cooperativity
  • Regulators Assembled for Non-identical Components
  • Speculations on Development and Evolution
  • Caveats
  • 6 Eukaryotic Gene Regulation - Experiments and Examples:Background
  • Two Functions of an Activator: DNA Binding and Activation
  • DNA Binding Structures
  • Activating Regions
  • Action at a Distance- Looping
  • Activation In Vivo and In Vitro
  • Squelching
  • Repression
  • Regulators Assembled from Non-identical Components
  • More Cooperativity
  • The Case of Eve
  • Conclusion
  • Appendix 1 Designing an Efficient DNA-binding Protein
  • Appendix 2 Strong and Weak Interactions
  • Appendix 3 Control of Transcription in Eukaryotes and Prokaryotes - a common mechanism

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