Integrative approaches to molecular biology / edited by Julio Collado-Vides, Boris Magasanik and Temple F. Smith.
Contributor(s): Collado-Vides, Julio
| Magasanik, Boris | Smith, Temple.
Material type: 
BookPublisher: Cambridge, Mass. : MIT Press, 1996Description: x, 345 pages : illustrations ; 26 cm.Content type: text Media type: unmediated Carrier type: volumeISBN: 0262032392 .Subject(s): Molecular biology -- CongressesDDC classification: 572.8 | Item type | Current library | Call number | Copy number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|---|
| General Lending | MTU Bishopstown Library Lending | 572.8 (Browse shelf(Opens below)) | 1 | Available | 00091829 |
Enhanced descriptions from Syndetics:
What are the main challenges of computational molecular biology once the genome projects are completed? Integrative Approaches to Molecular Biology focuses on molecular biology beyond sequences: from gene regulation to differentiation, a higher-level integration that will be a major theme in biology following conclusion of the genome program. It charts the course of the emerging discipline of integrative molecular biology from macromolecular sequences to a biological (and theoretical) perspective, showing that novel integrative methodologies and paradigms are emerging at the confluence of such disciplines as computer science, logic, linguistics, and mathematics.Following an introductory chapter by Richard Lewontin that offers a critique of the evolutionary process as one of engineering design, the first part of the book, on computational biology, addresses issues concerning protein and DNA sequences within genome projects and a federated infrastructure for databases. The second part brings together experimental, evolutionary, computational, and theoretical approaches dealing with regulation of gene expression, metabolic pathways, and cell differentiation. The book concludes with a chapter on problems and perspectives on artificial intelligence.
Consequence of a meeting held at the Center for Nitrogen Fixation, National Autonomous University of Mexico, Cuernavaca, in Feb. 1994.
Bibliography: p. 303-330. - Includes index.
Evolution as engineering / Richard C. Lewontin -- I Computational biology: Analysis of bacteriophage T4 based on the completed DNA sequence / Elizabeth Kutter -- The identification of protein functional patterns / Temple F. Smith, Richard Lathrop and Fred E. Cohen -- Comparative genomics: a new integrative biology / Robert J. Robbins -- On Genomes and cosmologies / Antoine Danchin -- II Regulation, metabolism and differentiation: experimental and theoretical integration: A kinetic formalism for integrative molecular biology: manifestation in biochemical systems theory and use in elucidating design principles for gene circuits / Michael A. Savageau -- Genome analysis and global regulation in escherichia coli / Frederick C. Neidhardt -- Feedback loops: the wheels of regulatory networks / Rene Thomas -- Integrative representations of the regulation of gene expression / Julio Collado-Vides -- Eukaryotic transcription / Thomas Oehler and Leonard Guarente -- Analysis of complex metabolic pathways / Michael L. Mavrovouniotis -- Where do biochemical pathways lead? / Jack Cohen and Sean H. Rice -- Gene circuits and their uses / John Reinitz and David H. Sharp -- Fallback positions and fossils in gene regulation / Boris Magasanik -- The language of the genes / Robert C. Berwick.
Reviews provided by Syndetics
CHOICE Review
The outgrowth of a 1994 conference, this collection sets the ambitious goal to look beyond reductionist approaches to molecular biology, including the current genome sequencing efforts, to ask how this burgeoning body of information can be integrated to understand higher-order biological processes. The first of two sections, "Computational Biology," focuses on strategies for organizing the ever-growing DNA sequence and related information into flexible, powerful databases and methods for its subsequent analysis. The second section, "Regulation, Metabolism, and Differentiation: Experimental and Theoretical Integration," provides some fascinating insight into the variety of approaches being used to integrate molecular biology information into computational models that can explain more complex processes. Like many collections of works by various authors, Integrative Approaches suffers some from a lack of cohesiveness. Additionally, the contributions vary in their timeliness (few references in the extensive bibliography date beyond 1994) and accessibility to most undergraduate students. Though individual articles on these topics are available elsewhere (many are noted at the end of each article), this volume is valuable in providing a unique collection of essays highlighting approaches for investigating the next frontier of molecular biology. Graduate students and above. W. R. Morgan; College of WoosterAuthor notes provided by Syndetics
Julio Collado-Vides is Professor and Head of the Laboratory of Computational Biology at the Universidad Nacional Aut#65533;noma de M#65533;xico, Cuernavaca. He is coeditor of Integrative Approaches to Molecular Biology (MIT Press, 1996).