Enhanced descriptions from Syndetics:

This text, drawing upon the range of toxicology literature, sets down the fundamental principles of toxicology and pharmacology and goes on to cover recent developments in the field. The emphasis of the book is on biomechanical mechanisms. This second edition contains more examples.

Table of contents provided by Syndetics

• Preface (p. x)
• Chapter 1 Introduction (p. 1)
• 1.1 Background (p. 1)
• 1.2 Scope (p. 1)
• 1.3 Biochemical aspects of toxicology (p. 2)
• 1.4 Summary (p. 4)
• 1.5 Review questions (p. 5)
• 1.6 Bibliography (p. 5)
• Chapter 2 Dose-response relationships (p. 7)
• 2.1 Introduction (p. 7)
• 2.2 Criteria of toxicity (p. 7)
• 2.3 Dose-response (p. 11)
• 2.4 Measurement of dose-response relationships (p. 16)
• 2.5 Hazard and risk assessment (p. 20)
• 2.6 Chronic toxicity (p. 21)
• 2.7 Summary (p. 22)
• 2.8 Review questions (p. 22)
• 2.9 Bibliography (p. 22)
• Chapter 3 Factors affecting toxic responses: disposition (p. 25)
• 3.1 Absorption (p. 25)
• 3.2 Sites of absorption (p. 33)
• 3.3 Distribution (p. 42)
• 3.4 Excretion (p. 55)
• 3.5 Summary (p. 60)
• 3.6 Review questions (p. 61)
• 3.7 Bibliography (p. 62)
• Chapter 4 Factors affecting toxic responses: metabolism (p. 65)
• 4.1 Introduction (p. 65)
• 4.2 Types of metabolic change (p. 67)
• 4.3 Phase 1 reactions (p. 68)
• 4.4 Phase 2 reactions (p. 95)
• 4.5 Control of metabolism (p. 106)
• 4.6 Toxication versus detoxication (p. 107)
• 4.7 Summary (p. 109)
• 4.8 Review questions (p. 110)
• 4.9 Bibliography (p. 110)
• Chapter 5 Factors affecting metabolism and disposition (p. 113)
• 5.1 Introduction (p. 113)
• 5.2 Chemical factors (p. 114)
• 5.3 Biological factors (p. 117)
• 5.4 Summary (p. 169)
• 5.5 Review questions (p. 171)
• 5.6 Bibliography (p. 172)
• Chapter 6 Toxic responses to foreign compounds (p. 175)
• 6.1 Introduction (p. 175)
• 6.2 Direct toxic action: tissue lesions (p. 176)
• 6.3 Pharmacological, physiological and biochemical effects (p. 211)
• 6.4 Teratogenesis (p. 215)
• 6.5 Immunotoxicity (p. 227)
• 6.6 Genetic toxicity (p. 233)
• 6.7 Chemical carcinogenesis (p. 243)
• 6.8 Summary (p. 250)
• 6.9 Review questions (p. 252)
• 6.10 Bibliography (p. 253)
• Chapter 7 Biochemical mechanisms of toxicity: specific examples (p. 259)
• 7.1 Chemical carcinogenesis (p. 259)
• 7.2 Tissue lesions: liver necrosis (p. 269)
• 7.3 Tissue lesions: kidney damage (p. 285)
• 7.4 Tissue lesions: lung damage (p. 290)
• 7.5 Neurotoxicity (p. 294)
• 7.6 Exaggerated and unwanted pharmacological effects (p. 297)
• 7.7 Physiological effects (p. 304)
• 7.8 Biochemical effects: lethal synthesis and incorporation (p. 307)
• 7.9 Biochemical effects: interaction with specific protein receptors (p. 311)
• 7.10 Teratogenesis (p. 316)
• 7.11 Immunotoxicity (p. 321)
• 7.12 Multi-organ toxicity (p. 330)
• 7.13 Multi-organ toxicity: metals (p. 334)
• 7.14 Summary (p. 341)
• 7.15 Review questions (p. 348)
• 7.16 Bibliography (p. 349)
• Answers to review questions (p. 354)
• Glossary (p. 365)
• Index (p. 378)

Author notes provided by Syndetics