Enhanced descriptions from Syndetics:

An explanation of how a new view on the regulation of metabolism has been opened by the theory of metabolic control analysis. It brings together a full explanation of the new theory with an account of its experimental implementation since its origins in the 1970s. As well as noting the differences between metabolic control analysis and traditional metabolic biochemistry, the books describes the background of enzyme kinetics and metabolic investigations on which this new theory draws.

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CHOICE Review

Fell critically evaluates the assumptions of existing analyses of enzyme reactions from the perspective of actual/likely cellular conditions (which are rarely approximated in the test tube). He expands on material commonly found in biochemistry texts, with a particular emphasis on the interconnectedness of real enzymatic cycles, and makes a compelling case (with computer and molecular biological models) for the oversimplified approach of existing models of metabolic regulation. Using a relatively new approach called metabolic control analysis, the author attempts to quantitatively evaluate existing published data by applying the analysis techniques and equations of metabolic control analysis to published data. Using this approach he addresses issues of rate-limiting nature of the enzyme rubisco, the effects of enzyme inhibitors on flux through complex metabolic pathways, and the contribution of a single enzyme to the overall functioning of a complex pathway. Though much of the material is not new, the perspective on metabolism offered in this text is a fresh and thoughtful approach that will be of interest to investigators of biochemical reactions. Graduate; faculty. K. M. Susman; Vassar College