A guide to pharmaceutical particulate science [electronic book] / Timothy M. Crowder.
By: Crowder, Timothy M [author]
.
Material type: 
BookBoca Raton, Fla. : Interpharm Press/CRC, c2003Description: online resource (x, 241 pages) : illustrations.Content type: text Media type: computer Carrier type: online resourceISBN: 9781574911428 (hardback); 9780203009673 (e-book).Subject(s): Powders (Pharmacy) | Particles | Drugs -- Dosage formsAdditional physical formats: Print version: A guide to pharmaceutical particulate science.DDC classification: 615.43 Online resources: E-book Also available in print format.| Item type | Current library | Call number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|
| e-BOOK | MTU Bishopstown Library eBook | 615.43 (Browse shelf(Opens below)) | Not for loan |
Enhanced descriptions from Syndetics:
The pharmaceutical applications of powder technology have long been recognized. Yet while many books focus on aspects of powder formation and behavior, there has been no text that explores the power of particulate science in the design, manufacture, and control of quality medicines. Until now. A Guide to Pharmaceutical Particulate Science discusses key principles of particulate science and their practical applications.
The authors cover particulate material, its form and production, sampling from bodies of powder, particle size descriptors and statistics, behavior of particles, instrumental analysis, particle size measurement and synergy of adopted techniques, physical behavior of a powder, and in vitro and in vivo performance criteria. They draw the components of particulate science into a single concise description of their current and potential uses in product development. Exploring the growth in knowledge of particle properties and the variety of technological advances in particle manufacture, A Guide to Pharmaceutical Particulate Science gives readers the tools they need to grasp the science and its use in the industry.
Includes bibliographical references (pages 207-231) and index.
Particulate systems: manufacture and characterization -- Sampling and measurement biases -- Particle size descriptors and statistics -- Behavior of particles -- Instrumental analysis -- Methods of particle size measurement and their importance for specific applications (instrument synergy) -- Particle size behavior and physical behavior of a powder -- Clinical effect of pharmaceutical particulate systems.
CIT Module CHEA 8004 - Core reading.
Also available in print format.
Electronic reproduction.: ProQuest LibCentral. Mode of access: World Wide Web.
Table of contents provided by Syndetics
- Preface (p. ix)
- 1. Introduction and Overview (p. 1)
- Situation Analysis (p. 1)
- Quality of Published Data on Particle Size in Pharmaceuticals (p. 2)
- The Future of Crystal Engineering (p. 2)
- Chemistry and Pharmacy Regulatory Submissions (p. 2)
- Misconceptions and Misunderstandings of Particulate Science (p. 3)
- Powerful Methods Complementary to Particle Sizing (p. 3)
- Integration of Particle Sizing Methods with Their In-Use Situation (p. 4)
- Adjacencies and Interactions Between Particles (p. 5)
- Lessons from Other Industries (p. 5)
- Pharmaceutical Particulate Science as a Core Educational Requirement (p. 6)
- Particle Characterization and Its Impact on Regulatory Submissions from Formulation through Toxicology and Efficacy (p. 6)
- Conclusion (p. 7)
- 2. Particulate Systems: Manufacture and Characterization (p. 9)
- States of Matter (p. 9)
- Crystalline Solids (p. 11)
- Crystal Symmetry (p. 11)
- Euler's Relationship (p. 12)
- Crystal Systems (p. 13)
- Miller Indices (p. 14)
- Space Lattices (p. 14)
- Solid State Bonding (p. 14)
- Isomorphs and Polymorphs (p. 16)
- Enantiomorphs and Racemates (p. 16)
- Crystal Habit (p. 18)
- Crystal Imperfections (p. 18)
- Methods of Particle Production (p. 19)
- Particulate Systems (p. 21)
- Conclusion (p. 26)
- 3. Sampling and Measurement Biases (p. 27)
- Sampling Strategies (p. 28)
- Statistical Analyses (p. 32)
- Sampling Techniques (p. 33)
- Segregation (p. 40)
- Sampling (p. 44)
- Sampling Errors (p. 51)
- Preparation Errors (p. 52)
- Particle Size Measurement Errors (p. 54)
- Conclusions (p. 57)
- 4. Particle Size Descriptors and Statistics (p. 59)
- Particle Size Descriptors (p. 62)
- Particle Size Statistics (p. 67)
- Mathematical Distributions (p. 70)
- Applications (p. 73)
- Conclusion (p. 75)
- 5. Behavior of Particles (p. 77)
- Physical Properties (p. 77)
- Particle Adhesion (p. 86)
- Particle Motion in Bulk Powders (p. 103)
- Particle Motion in Gaseous Dispersions (p. 111)
- Particle Motion in Liquid Media (p. 115)
- Conclusion (p. 119)
- 6. Instrumental Analysis (p. 123)
- Direct Imaging (p. 124)
- Indirect Imaging (p. 134)
- Physical Methods of Particle Size Separation (p. 140)
- Approaches to Calibration (p. 147)
- Conclusions (p. 149)
- 7. Methods of Particle Size Measurement and Their Importance for Specific Applications (Instrument Synergy) (p. 151)
- An Essay on Measures of Diameters (p. 152)
- Conclusion (p. 154)
- 8. Particle Size and Physical Behavior of a Powder (p. 155)
- Selection of the Appropriate Particle Size Expression (p. 155)
- Powder Flow and Mixing (p. 156)
- Dispersion (p. 161)
- Granulation and Compression (p. 164)
- Conclusion (p. 165)
- 9. Clinical Effect of Pharmaceutical Particulate Systems (p. 167)
- Oral Delivery (p. 169)
- Parenteral Delivery (p. 177)
- Respiratory Delivery (p. 181)
- Nasal Delivery (p. 186)
- Transdermal and Topical Delivery (p. 189)
- Ocular Delivery (p. 193)
- Otic Delivery (p. 195)
- Buccal and Sublingual Delivery (p. 196)
- Rectal Delivery (p. 197)
- Vaginal Delivery (p. 198)
- Conclusions (p. 199)
- 10. General Conclusions (p. 201)
- References (p. 207)
- Index (p. 233)