Enhanced descriptions from Syndetics:

A practical guide to laboratory diagnosis and treatment of hemostatic disorders.

This concise book covers all you need to know to manage thrombotic and bleeding disorders, distilling the most clinically up-to-date information, and including the latest treatment strategies for key conditions and diseases. Essential Guide to Blood Coagulation covers both the stable and the acute stages of hereditary and acquired bleeding and thrombotic disorders.

Faced with a bleeding patient, it may be difficult to determine whether blood loss is due to a local factor or an underlying hemostatic defect. There are a range of laboratory tests which can be performed to identify the cause of bleeding in a patient. This book highlights the tests that can be used in the laboratory to aid diagnosis.

Originally published in Swedish, Essential Guide to Blood Coagulation , has been revised to include the latest treatment strategies available for patients and will help clinicians to expand their knowledge of hemostatic disorders .

Table of contents provided by Syndetics

• 1 Preface General Hemostasis
• 2 Schematic Presentation of the Hemostatic System
• 3 Proposals For Investigation and Sampling Instructions
• Increased bleeding tendency
• Screening analyses
• Venous thromboembolism
• Arterial thromboembolism
• Preanalytical consideration to note in the patient prior to sampling
• Resting before sampling, position at sampling, sampling occasion etc
• 4 Laboratory Investigation
• Nomenclature
• Reference intervals for laboratory investigations
• Screening analyses
• Pt-Bleeding time
• B/CB-PLT (platelet particle concentrations equals number of platelets)
• P-APT-time (activated partial thromboplastin time)
• P-B/CB-Prothrombin complex
• P-B/CB-Pt (INR)
• Special analyses
• Coagulation factors
• Anticoagulants
• Natural coagulation inhibitors
• Platelet function
• Fibrinolysis
• Markers for coagulant activation (Hyper-coagulation markers)
• DNA analyses
• DNA analysis of hemophilia A and B
• DNA analysis in thrombotic disorders
• Useful components in research studies
• Other non-hemostatic variables of importance
• 5 Imaging Diagnostic Procedures Bleeding Disorders
• 6 Hereditary Bleeding Disorders Severe Forms
• Factor concentrates used in treatment of hemophilia A, B and VWD
• Treatment strategy in severe forms of hemophilia and VWD
• Painkilling drugs allowed in hemophilia and VWD
• Side effects above all at treatment of severe forms of hereditary bleeding disorders
• Treatment principles for different forms of bleeding disorders (severe, moderate and milder forms of hemostatic defects)
• Delivery
• Treatment with tranexamic acid
• Severe platelet function defects e.g. thrombastenia Glanzmann
• Mild Hemostatic Defects
• General remarks
• Treatment in general
• Treatment with desmopressin (Octostim)
• Blood sampling in hemophilia patients
• Bleeding risk charts (suggestion for)
• 7 Serious Non-Hereditary Bleedings
• Introduction
• Massive bleedings
• Transfusion coagulopathy
• Treatment
• Complicating factors
• 8 Investigations Of Increased Bleeding Tendency
• Background
• Diagnosis
• Suggested questions for bleeding history
• Laboratory tests (see also above)
• Explanations for pathological screening analyses and further actions
• Prolonged bleeding time
• Thrombocytopenia
• Prolonged APT-time
• Elevated PT (INR)
• Investigations of bleeding tendency; practical aspects
• Thromboembolic Disorders
• 9 Venous Thrombosis And Pulmonary Embolism
• Introduction
• Diagnosis of venous thrombosis
• Tools for confirming or discarding a clinical suspicion of a venous thrombosis
• Superficial thrombophlebitis
• Diagnosis of pulmonary embolism
• Tools for confirming or excluding clinical suspicion of pulmonary embolism
• Non Pharmacological Treatment Of Dvt And Pe
• Drug Treatment In Dvt And Pe
• Heparin (UFH) and low molecular weigh heparin (LMH)
• Treatment of superficial thrombophlebitis
• Bleeding complications in treatment with UFH and LMH
• Thrombolytical treatment
• Thrombolytic drugs
• Bleeding complications in thrombolytic treatment
• Secondary prophylaxis against DVT and PE with AVK drugs
• Practical advice: patients treated with AVK drugs
• Elective adjustment of PT(INR) prior to risk situations e.g. tooth extraction, surgery etc
• Bleeding during treatment with UFH/LMH, thrombin inhibitors and pentasaccarides
• Primary Prophylaxis Against Dvt And Pe
• 10 Arterial Thromboembolism
• Ischemic heart disease
• Unstable angina pectoris/non ST-elevation myocardial infarction (NONSTEMI)
• ST-elevating myocardial infarction (STEMI)
• Cardiac arrhythmias (atrial fibrillation)
• Peripheral artery diseases
• Surgery on peripheral arteries
• Cerebral ischemia
• Thrombolysis in stroke
• Recurrent TIA
• 11 Investigations Of Thromboembolic Tendency
• Special Hemostasis
• 12 Hemostatic Defects In Obstetrics And Gynecology
• Thrombosis during pregnancy
• Treatment in acute DVT/PE during pregnancy and at partus
• Breast feeding
• Special cases
• Treatment of women with mechanical heart valve prothesis
• Thromboprophylaxis during pregnancy, partus and post partum
• Dosage of LM-heparin (LMH) in thromboprophylaxis
• Thromboprophylaxis at Caesarean section
• Obstetric epidural/spinal analgesia (anaesthesia)
• Complications during pregnancy
• Thromboprophylaxis in legal and spontaneous abortions
• Thromboprophylaxis in gynecological surgery
• Oral contraceptives, hormone substitution and surgery
• Investigation prior to artificial insemination
• Investigation prior to oral contraceptives, advice concerning oral contraceptives
• Investigation prior to post-climacteric substitution treatment (HRT=hormone replacement therapy)
• Investigation in repeated miscarriages
• Investigation in menorrhagia
• 13 Hemostatic Defects In Children
• Bleedings
• Introduction
• Bleeding in newborns
• Coagulation factor deficiencies
• Acquired bleeding tendency
• Thromboembolic disease in children
• Introduction
• Venous thrombosis
• Sinus thrombosis
• Arterial thrombosis
• Stroke
• 14 Emergency Conditions Associated With Activation Of Coagulation
• Disseminated intravascular coagulation (DIC)
• Definition
• Pathophysiology
• Clinical picture
• Laboratory diagnosis
• Treatment
• Coagulatopathy in septic shock
• Heparin-induced thrombocytopenia
• Thrombotic microangiopathies (TTP and HUS)
• List of components and analyses

Author notes provided by Syndetics

Professor Margareta Blomback, MD, PhD, Emeritus Professor, Coagulation Research Laboratory, Karolinska Institute and Hospital, Sweden. Professor Blomback served as Chair of the Scientific & Standardization Committee of the ISTH and is co-chair of the working party on women's issues in haemostasis and thrombosis. Professor Blomback has published almost 500 papers and is world renowned as an expert in blood coagulation.

Dr Jovan Antovic, Coagulation Research Laboratory, Karolinska Institute and Hospital, Sweden. Dr Antovic is author or coauthor of about 30 articles published in peer-review scientific journals and serves as a reviewer for journals in the field of haematology and haemostasis (e.g. Journal of Thrombosis & Haemostasis, Atherosclerosis, Thrombosis & Vascular Biology, Circulation). He is also a member of the Editorial Board of Haemostasis Forum, and teaches on under- and postgraduate level courses.