Enhanced descriptions from Syndetics:

In this ground-breaking book Dr. Jan Karlsson presents his latest findings on nutratherapy, focusing on vitamins Q E, and F1 and how they relate to exercise, sports, and health.

Among the world's leading researchers on radicals and antioxidants, Karlsson explains the relationship between

- nutratherapy and preventive medicine,
- muscle metabolism and radical-antioxidant biology,
- muscle biochemistry and food choices, and
- foods, food supplements, and physical performance.

Clearly written and thoroughly illustrated, Antioxidants and Exercise contains the latest research on nutratherapy and how it can enhance performance.

Table of contents provided by Syndetics

• Section I Introduction to Nutraology (p. 1)
• Chapter 1 Introduction (p. 2)
• History of Radical and Antioxidant Science (p. 2)
• Topics to Be Discussed (p. 5)
• Applicability of Nutratherapy to Recreational Exercise and Elite Sport (p. 6)
• Chapter 2 Historical Perspective (p. 7)
• Introduction of New Concepts (p. 8)
• Nutratherapy and Health Promotion (p. 10)
• Vitamin Terminology (p. 13)
• Vitamins and Enzymology (p. 15)
• Exclier Nutraceutical Concepts (p. 16)
• Nutratherapy as a Potential Risk Factor (p. 18)
• Radical Trauma in People Who Exercise (p. 20)
• Summary (p. 21)
• Section II Radical Formation (p. 22)
• Chapter 3 Principles of Radical Formation (p. 25)
• Definition of the Term Radical (p. 25)
• Metabolism and Radical Formation (p. 26)
• Radical Formation in the Service of Life (p. 31)
• Radical Formation and Cell Protection: The Antioxidant Strategy (p. 33)
• Principles of the Cascade Reaction (p. 34)
• Fenton Reactions (p. 35)
• Biologically Significant Radicals (p. 37)
• Summary (p. 38)
• Chapter 4 Principles of Radical Quenching (p. 39)
• Uniqueness of Phenol Structures (p. 40)
• Phenol Species and Their Scavenging Potentials (p. 43)
• Radical Scavenging (p. 45)
• Water Solubility and Antioxidant Allocation (p. 48)
• Other Antioxidant Compounds (p. 50)
• Quenching of Singlet Oxygen (p. 52)
• Summary (p. 53)
• Chapter 5 Antioxidants--Recycling Systems or Irreversible Reactions? (p. 54)
• Design of Recycling Systems in Biology (p. 56)
• Vitamin Q as a Coenzyme in Mitochondria (p. 58)
• Antioxidants and Reversible Processes/Reactions (p. 59)
• Irreversible Reactions (p. 61)
• Vitamin Q, Mitogenic Ligands, and Training (p. 63)
• Cycling Antioxidants and Antioxidant Enzymes (p. 66)
• Summary (p. 68)
• Chapter 6 Radical Formation in Different Cells and Tissues (p. 69)
• Muscle Activity and Mitochondrial Metabolism (p. 70)
• Muscle Exercise, Purine Metabolism, and Radicals (p. 81)
• Endothelial Tissue (p. 81)
• White Blood Cells and Radical Formation (p. 84)
• Miscellaneous (p. 87)
• Concept of Overuse Injury (p. 88)
• Summary (p. 88)
• Chapter 7 Exercising Muscle and Radical Formation (p. 91)
• Biological Evidence of Free Radicals (p. 91)
• Fingerprinting in Humans (p. 92)
• Summary (p. 95)
• Chapter 8 Nutrients as Antioxidants and Their Food Sources (p. 97)
• Food Sources for Antioxidant Nutrients (p. 98)
• Antioxidant-Related Nutrients (p. 101)
• Summary (p. 106)
• Chapter 9 Exercise, Mixed Diets, and Nutratherapy (p. 108)
• Muscle Exercise and Its Limitations (p. 109)
• Muscle Activity and Energy Intake (p. 110)
• Energy Intake and "Natural Nutrients" (p. 112)
• Elite Sport Activity and Antioxidant Nutratherapy (p. 114)
• Inflammatory Processes and Nutratherapy (p. 115)
• Diet Antioxidants or Nutratherapy (p. 119)
• Antioxidant and Omega-3 Fatty Acid Nutratherapy (p. 120)
• Antioxidants and Other Nutrients (p. 123)
• Summary (p. 125)
• Chapter 10 Lipoidic Structures, Lipophilic Antioxidants, and Clinical Interpretations (p. 127)
• Antioxidant Allocation and Its Significance (p. 128)
• Antioxidants in Different Organs and Tissues (p. 129)
• Plasma Lipophilic Antioxidants and Their "Normalization" (p. 132)
• Vitamins Q and E in Plasma HDL and LDL Particles (p. 137)
• Vitamins Q and E and Their Transport Vehicle--LDL (p. 138)
• Vitamins Q and E and Their Turnover: A Role for HDL? (p. 141)
• Endowment and Training Adaptation and Antioxidants (p. 141)
• Summary (p. 143)
• Section III Nutratherapy and Sports Medicine (p. 144)
• Chapter 11 Relevant Studies (p. 146)
• Antioxidant Vitamins and Placebo-Controlled Studies (p. 146)
• Antioxidant Supplements and Open Studies (p. 147)
• Good Clinical Trial Practice Studies (p. 150)
• Summary (p. 161)
• Chapter 12 Nutratherapy, Dose Response, and Side Effects (p. 163)
• Nutratherapies and Their Pharmacokinetics (p. 163)
• Antioxidant Supplements and Tissue Changes (p. 165)
• Dose-Response Curves for Antioxidants (p. 167)
• Standardized or Individualized Nutratherapy? (p. 169)
• Side Effects of Vitamins Q, E, and F[subscript 1] (p. 170)
• Summary (p. 173)
• Chapter 13 Nutrients, Pharmaceutical Grade, and the Doping Issue (p. 175)
• Supplement Products and Good Manufacturing Practice (GMP) (p. 176)
• Nutraceutical Therapy, Ergogenic Aids, and Sport Ethics (p. 177)
• Elite Sport, "Drugs," and the Doping Rules (p. 178)
• Section IV Conclusions (p. 180)
• References (p. 183)
• Index (p. 202)
• About the Author (p. 211)

Author notes provided by Syndetics

Jan Karlsson, PhD, has conducted academic research on muscle metabolism for more than 30 years and on radicals and antioxidants for more than 15 years.

Karlsson served as a visiting professor in the Institute for Biomedical Research at the University of Texas-Austin from 1981 to 1991. He was director of the Human Performance Laboratory at Karolinska Hospital in Stockholm, Sweden, from 1977 to 1982, and acting professor in sport exercise physiology at the Karolinska Institute from 1974 to 1977. Karlsson received his DrSci in 1971 and completed his post-doctoral work at Parkland Memorial Hospital in Dallas, Texas, in 1974.

Karlsson has written more than 250 articles and reviews about muscle physiology, molecular cardiology, exercise physiology, clinical cardiology, and drug testing, and he serves as a consultant to several major international pharmaceutical companies. He has received awards for his contributions in exercise medicine and drug development in Finland, the former West Germany, and Japan.