Enhanced descriptions from Syndetics:

The use of biocatalysts, employed either as isolated enzymes or whole cells, offer a remarkable arsenal of highly selective transformations for modern preparative organic chemistry. During the past decade, this methodology has now generally been accepted as a complementary method to the already existing tools. The setup of this first textbook on biocatalysis is based on a professional reference book published in 1992, and it provides a basis for undergraduate and graduate courses in biocatalysis, as well as a condensed introduction into this field for scientists and professionals. After a basic introduction into the use of biocatalysts - principles of stereoselective transformations, kinetics, enzyme nomenclature and -handling, the different types of reactions are explained according to the "reaction principle".

Table of contents provided by Syndetics

• Preface
• 1 Introduction and Background Information
• 1.1 Introduction (p. 1)
• 1.2 Common Prejudices Against Enzymes (p. 1)
• 1.3 Advantages and Disadvantages of Biocatalysts (p. 3)
• 1.3.1 Advantages of Biocatalysts (p. 3)
• 1.3.2 Disadvantages of Biocatalysts (p. 7)
• 1.3.3 Isolated Enzvmcs versus Whole Cell Svstems (p. 9)
• 1.1 Enzyme Properties and Nomenclature (p. 11)
• 1.4.1 Mechanistic Aspects (p. 12)
• 1.4.2 Classification and Nomenclature (p. 21)
• 1.4.3 Coenzymes (p. 24)
• 1.4.4 Hnzyme Sources (p. 25)
• References|26
• 12 Biocatalytic Applications
• 2.1 Hvdrolvtic Reactions (p. 29)
• 2.1.1 Mechanistic and Kinetic Aspects (p. 29)
• 2.1.2 Hvdrolvsis of the Amide Bond (p. 52)
• 2.1.3 Ester Hydrolysis (p. 63)
• 2.1.3.1 Esterases and Proteases (p. 63)
• 2.1.3.2 Lipases (p. 94)
• 2.1.4 Hydrolysis and Formation of Phosphate Esters (p. 123)
• 2.1.5 Hydrolysis of Epoxides (p. 135)
• 2.1.6 Hydrolysis of Nitriles (p. 149)
• References (p. 159)
• 2.2 Reduction Reactions1 (p. 77)
• 2.2.1 Recycling of Cofaclors (p. 177)
• 2.2.2 Reduction of Aldehydes and Kelones Using Isolated Enzymes (p. 184)
• 2.2.3 Reduction of Aldehydes and Ketones Using Whole Cells (p. 192)
• 2.2.4 Reduction of C=C-Bonds Using Whole Cells (p. 206)
• References (p. 213)
• 2.3 Oxidation Reactions (p. 220)
• 2.3.1 Oxidation of Alcohols and Aldehydes (p. 220)
• 2.3.2 Oxygenation Reactions (p. 225)
• 2.3.2.1 Hydroxylatiou of Alkanes (p. 230)
• 2.3.2.2 Hydroxylatiou of Aromatic Compounds (p. 234)
• 2.3.2.3 Epoxidation of Alkenes (p. 236)
• 2.3.2.4 Sulfoxidation Reactions (p. 240)
• 2.3.2.5 Baeyer-Viliiger Reactions (p. 242)
• 2.3.2.6 Formation of Peroxides (p. 249)
• 2.3.2.7 Dihydroxylation of Aromatic Compounds (p. 253)
• 2.3.3 Peroxidation Reactions (p. 256)
• References (p. 264)
• 2.4 Formation of Carbon-Caxbon Bonds (p. 273)
• 2.4.1 Aldol-Reactions (p. 273)
• 2.4.2 Acyloin-Reactious (p. 289)
• 2.4.3 Michael-Type Additions (p. 292)
• References (p. 294)
• 2.5 Addition and Elimination Reactions (p. 298)
• 2.5.1 Cyanohydrin Formation (p. 298)
• 2.5.2 Addition of Water and Ammonia (p. 302)
• References (p. 305)
• 2.6 Glycosyl-Transfcr Reactions (p. 307)
• 2.6.1 Glycosyl Transferases (p. 307)
• 2.6.2 Glycosidascs (p. 311)
• References (p. 319)
• 2.7 Haiogcnation and Dehalogeaalion Reactions (p. 322)
• 2.7.1 Halogenation (p. 322)
• 2.7.2 Dehalogenation (p. 327)
• References (p. 332)
• 3 Special Techniques
• 3.1 Enzymes in Organic Solvents (p. 334)
• 3.1.1 Ester Synthesis (p. 344)
• 3.1.2 Lactone Synthesis (p. 366)
• 3.1.3 Amide Synthesis (p. 367)
• 3.1.4 Peptidc Synthesis (p. 370)
• 3.1.5 Peracid Synthesis (p. 377)
• 3.1.6 Redox Reactions (p. 378)
• 3.1.7 Medium Engineering (p. 381)
• 3.2 Immobilization (p. 384)
• 3.3 Modified and Artificial Enzymes (p. 397)
• 3.3.1 Modified Enzymes (p. 397)
• 3.3.2 Semisynthetic Enzymes (p. 401)
• 3.3.3 Catalytic Antibodies (p. 403)
• References (p. 408)
• 4 State of the Art and Outlook (p. 419)
• 5 Appendix
• 5.1 Basic Rules for Handling Biocatalysts (p. 425)
• 5.2 Abbreviations (p. 429)
• 5.3 Suppliers of Enzymes (p. 430)
• 5.4 Commonly Used Enzyme Preparations (p. 431)
• 5.5 Major Culture Collections (p. 434)
• 5.6 Pathogenic Bacteria and Fungi (p. 435)
• Subject Index (p. 436)