Cellular microbiology / edited by Pascale Cossart ... [et al.].

Contributor(s): Cossart, Pascale | Boquet, P. (Patrice).

Material type: materialTypeLabel

BookPublisher: Washington, DC : ASM Press, 2000Description: xxii, 362 p. : ill. (some col.) ; 29 cm.ISBN: 1555811574.Subject(s): Infection

| Host-bacteria relationships

| Pathology, Cellular

DDC classification: 571.629

Contents:

Microbial pathogens: an overview / Pascale Cossart and Marc Lecuit -- Cell biology: an overview / Patrice Boquet -- Extracellular matrix and host cell surfaces: potential sites of pathogen interaction / Klaus T. Preissner and G. Singh Chhatwal -- Bacterial adherence to cell surfaces and extracellular matrix / B. Brett Finlay and Michael Caparon -- Molecular basis for cell adhesion and adhesion-mediated signaling / Benjamin Geiger, Avril Ben-Ze'ev, Eli Zamir and Alexander D. Bershadsky -- Cell adhesion molecules and bacterial pathogens / Guy Tran Van Nhieu and Philippe J. Sansonetti -- Membrane trafficking in the endocytic pathway of eukaryotic cells / Raluca Gagescu and Jean Gruenberg -- Where to stay inside the cell: a homesteader's guide to intracellular parasitism / David G. Russell -- Actin filaments: self-assembly and regulatory interactions / Frederick S. Southwick and Daniel L. Purich -- Bacterial manipulation of the host cell cytoskeleton / Sandra J. McCallum and Julie A. Theriot -- Bacterial Toxins / Rino Rappuoli and Mariagrazia Pizza -- Bacterial protein toxins as tools in cell biology and pharmacology / Klaus Aktories -- Type III secretion systems in animal- and plant- interacting bacteria / Kurt Schesser, Matthew S. Francis, Ake Forsberg and Hans Wolf-Watz -- Bacterial type IV secretion systems: DNA conjugation machines adapted for export of virulence factors / Peter J. Christie and Antonello Covacci -- Induction of apoptosis of microbial pathogens / Jeremy E. Moss, Ilona Idanpaan-Heikkila and Arturo Zychlinsky -- Interaction of pathogens with the innate and adaptive immune system / Emil R. Unanue -- Microscopy / Chantal de Chasellier -- Promising new tools for virulence gene discovery / Timothy K. McDaniel and Raphael H. Validivia.

Holdings
Item type	Current library	Call number	Copy number	Status	Date due	Barcode	Item holds
General Lending	MTU Bishopstown Library Lending	571.629 (Browse shelf(Opens below))	1	Available		00086361

Total holds: 0

Enhanced descriptions from Syndetics:

Cellular Microbiology is a new upper-level textbook which describes the interactions of microbes and pathogens in the wider context of the cell properties, helping the reader to envisage different possibilities for his or her own problem while detailing known specific examples. It provides microbiologists moving into cell biology with a deep understanding of the field as well as a broader knowledge of possible interactions between their favourite organism and mammalian cells. It also provides cell biologists with a comprehensive update of this emerging field.

Includes bibliographical references and index.

Table of contents provided by Syndetics

Contributors (p. xv)
Foreword (p. xvii)
Preface (p. xxi)
Chapter 1 Microbial Pathogens: an Overview (p. 1)
Bacteria (p. 1)
Strict Intracellular Bacteria (p. 1)
Facultative Intracellular Bacteria (Entry and Multiplication in Phagocytic Cells) (p. 6)
Facultative Intracellular Bacteria (Entry and Multiplication in Nonphagocytic Cells) (p. 7)
Nonsporulating Extracellular Bacteria (p. 11)
Sporulating Extracellular Bacteria (p. 20)
Parasites (p. 22)
Yeasts and Molds (p. 25)
Selected Readings (p. 27)
Chapter 2 Cell Biology: an Overview (p. 29)
General Cell Organization (p. 29)
Signal Transduction and Cell Regulation (p. 32)
Detection and Initial Transduction (p. 32)
Secondary Signal Transduction (p. 34)
Membrane Traffic (p. 37)
Organelle Biogenesis (p. 38)
The Cytoskeleton (p. 39)
Cell Adhesion and Morphogenesis (p. 42)
Apoptosis (p. 44)
Cell Cycle and Organelle Inheritance (p. 44)
Conclusion (p. 46)
Selected Readings (p. 47)
Chapter 3 Extracellular Matrix and Host Cell Surfaces: Potential Sites of Pathogen Interaction (p. 49)
Structural and Functional Components of the Extracellular Matrix (p. 49)
Collagens (p. 51)
Laminins (p. 52)
Elastin and Fibrillins (p. 52)
Proteoglycans and Hyaluronan (p. 53)
Adhesive Glycoproteins (p. 53)
Fibronectin (p. 54)
Vitronectin (p. 54)
Fibrinogen-Fibrin (p. 56)
Thrombospondin and Other "Matricellular" Proteins (p. 58)
ECM Degradation (p. 58)
Cell Surfaces and Bacterial Interactions (p. 59)
Lectins, Proteoglycans, and Mucins (p. 59)
Glycolipids (p. 60)
Cell Surface Adhesion Receptors (p. 61)
Conclusion (p. 63)
Selected Readings (p. 64)
Chapter 4 Bacterial Adherence to Cell Surfaces and Extracellular Matrix (p. 67)
Fimbriae of Gram-Negative Bacteria (p. 68)
P Pili: Model Fimbriae (p. 68)
Type IV Pili (p. 70)
Curli (p. 71)
Pathogens and Their Nonfimbrial Adhesins (p. 71)
Escherichia coli Afimbrial Adhesins (p. 71)
Helicobacter pylori (p. 72)
Bordetella pertussis (p. 72)
Neisseria Species (p. 73)
Yersinia Species (p. 73)
Mycobacterium Species (p. 74)
Staphylococcus and Streptococcus Species (p. 74)
Role of Adherence in Disease (p. 79)
Selected Readings (p. 80)
Chapter 5 Molecular Basis for Cell Adhesion and Adhesion-Mediated Signaling (p. 81)
Structural and Functional Diversity of Cell Adhesions (p. 81)
Transmembrane Interaction of the Extracellular Matrix with the Actin Cytoskeleton (p. 84)
Signaling Components in Matrix Adhesions (p. 87)
Molecular Interactions in Adherens Junctions (p. 90)
Signaling from Cell-Cell Adherens Junctions (p. 90)
Cross Talk between Adhesion-Dependent Signaling and the Rho Family GTPases (p. 91)
Tension-Dependent Activation of Adhesion-Mediated Signaling (p. 92)
Nonconventional Interactions Mediated by Specific Adhesion Receptors (p. 93)
Selected Readings (p. 94)
Chapter 6 Cell Adhesion Molecules and Bacterial Pathogens (p. 97)
Gaining Access to the Targets (p. 98)
Adhesion Molecules as Pathogen Receptors: Defining a Pathogen Strategy (p. 99)
Pathogen Adhesion as a Means of Host Tissue Tropism (p. 103)
Direct Interaction (p. 103)
Adherence via ECM Proteins: Bridging Mechanism (p. 103)
EPEC Adhesion: an Alternate Adhesion Mechanism (p. 104)
Intracellular Pathogens and Adhesion Molecules: Surviving the Macrophage or Breaching an Epithelium (p. 104)
Signaling via Adhesion Molecules and Pathogens (p. 106)
Focal Adhesions and Pathogen Entry (p. 106)
Up-Regulation of Adhesion Molecules (p. 108)
Conclusion (p. 110)
Selected Readings (p. 110)
Chapter 7 Membrane Trafficking in the Endocytic pathway of Eukaryotic Cells (p. 113)
Membrane Trafficking in Eukaryotic Cells (p. 113)
Organelles and Membrane Dynamics (p. 114)
Ways of Entry into the Cell (p. 115)
Endocytic Pathways (p. 115)
Phagocytic Pathways (p. 119)
Endosomes at the Crossroads of Membrane Traffic (p. 119)
Biosynthetic Pathway (p. 119)
Autophagy (p. 120)
Phagocytosis (p. 120)
Endocytic Pathway (p. 121)
Sorting in Early Endosomes (p. 121)
Recycling Pathway (p. 122)
Degradation Pathway (p. 123)
Sorting in Polarized Cells (p. 124)
Specialized Routes of Endocytic Membrane Transport (p. 125)
Molecular Mechanisms (p. 126)
Coat Proteins (p. 126)
Cytoskeleton (p. 127)
rab Proteins (p. 128)
SNARE Proteins, NSF, and SNAPs (p. 128)
Phosphoinositides (p. 129)
Membrane Microdomains (p. 129)
Annexins (p. 130)
Selected Readings (p. 130)
Chapter 8 Where To Stay inside the Cell: a Homesteader's Guide to Intracellular Parasitism (p. 131)
Routes of Invasion (p. 131)
Phagocytosis (p. 132)
Induced Endocytosis and Phagocytosis (p. 133)
Active Invasion (p. 133)
Selection of an Intracellular Niche (p. 134)
Intralysosomal Pathogens (p. 134)
Pathogens Sequestered in Modified or Isolated Vacuoles (p. 139)
Pathogens Resident in Host Cell Cytosol (p. 148)
Modulation of Intracellular Compartments by the Host Immune Response (p. 150)
Cell-Cell Spread (Metastasis) of Intracellular Pathogens (p. 151)
Conclusion (p. 152)
Selected Readings (p. 152)
Chapter 9 Actin Filaments: Self-Assembly and Regulatory Interactions (p. 153)
Basic Properties of Actin Monomers and Filaments (p. 154)
Actin Assembly Kinetics (p. 156)
Interactions of Regulatory Proteins with Actin Monomers and Filaments (p. 160)
Monomer-Binding Proteins (p. 161)
Actin Filament-Capping Proteins (p. 163)
Actin Filament-Severing Proteins (p. 165)
Actin Filament-Bundling and Cross-Linking Proteins (p. 165)
Actin-Depolymerizing Proteins (p. 165)
Other Actin-Regulatory Proteins (p. 165)
Polymerization Zone Model (p. 167)
Conclusion (p. 169)
Selected Readings (p. 169)
Chapter 10 Bacterial Manipulation of the Host Cell Cytoskeleton (p. 171)
Mechanisms of Bacterial Invasion (p. 173)
Zipper Mechanism of Bacterial Uptake by Nonphagocytic Cells (p. 174)
Trigger Mechanism of Bacterial Uptake by Nonphagocytic Cells (p. 176)
Preventing Phagocytosis (p. 180)
Yersinia Species (p. 180)
Bacterial Attachment without Invasion (p. 181)
Enteropathogenic Escherichia coli (p. 181)
Intracellular Motility and Intercellular Spread (p. 182)
Listeria monocytogenes (p. 183)
Shigella flexneri (p. 187)
Selected Readings (p. 190)
Chapter 11 Bacterial Toxins (p. 193)
Toxins Acting on the Cell Surface (p. 198)
Superantigens (p. 199)
Binding Domains of A/B Toxins (p. 200)
Toxins Cleaving Cell Surface Molecules (p. 201)
Pore-Forming Toxins (p. 201)
Soluble Toxins with an Intracellular Target (p. 205)
Toxins Acting on Protein Synthesis (p. 205)
Toxins Acting on Signal Transduction (p. 208)
Toxins Acting on G Proteins (p. 209)
Toxins Generating cAMP (p. 211)
Toxins Inactivating Cellular Kinases (p. 211)
Toxins Inducing Arrest in the G[subscript 2] Phase of the Cell Cycle (p. 211)
Toxins with Phospholipase C Activity (p. 212)
Toxins Modifying Small GTP-Binding Proteins (p. 212)
Toxins Acting on Vesicular Trafficking (p. 213)
Toxin Acting on Late Endosomes/Vacuoles (p. 215)
Toxins Acting on the Cytoskeleton (p. 215)
Toxins Directly Delivered by Bacteria into the Cytoplasm of Eukaryotic Cells (p. 216)
Proteins Acting on Phosphorylation (p. 217)
Proteins Acting on Small G Proteins (p. 217)
Proteins Altering Inositol Phosphate Metabolism (p. 218)
Apoptosis-Inducing Proteins (p. 218)
Proteins Acting on the Cytoskeleton (p. 219)
Cytotoxins with Unknown Mechanisms of Action (p. 219)
Selected Readings (p. 219)
Chapter 12 Bacterial Protein Toxins as Tools in Cell Biology and Pharmacology (p. 221)
Toxins as Tools To Study Nucleotide-Binding Proteins (p. 223)
Cholera Toxin and Pertussis Toxin as Tools To Study G-Protein-Mediated Signaling (p. 223)
Toxins as Tools To Study the Regulation of the Actin Cytoskeleton (p. 225)
Actin ADP-Ribosylating Toxins (p. 226)
Toxins That Affect Small GTPases (p. 229)
Rho-Inactivating Toxins (p. 231)
Rho-Activating Toxins (p. 234)
Toxins as Part of a Transmembrane Carrier System (p. 234)
Clostridial Neurotoxins as Tools To Study Exocytosis (p. 235)
Toxins as Tools for Permeabilization of Eukaryotic Cells (p. 236)
Selected Readings (p. 237)
Chapter 13 Type III Secretion Systems in Animal- and Plant-Interacting Bacteria (p. 239)
Type III Secretion Systems (p. 245)
Secretion Apparatus (p. 246)
Secreted Proteins (p. 250)
Chaperone Proteins (p. 252)
Delivery and Effectors (p. 253)
Injection System (p. 253)
Effectors (p. 255)
Conclusion (p. 262)
Selected Readings (p. 262)
Chapter 14 Bacterial Type IV Secretion Systems: DNA Conjugation Machines Adapted for Export of Virulence Factors (p. 265)
Members of the Type IV Secretion Family (p. 265)
The A. tumefaciens T-Complex Transfer System as a Paradigm for Assembly of Type IV Secretion Systems (p. 268)
Substrate Recognition and the Export Route (p. 269)
Molecular Cell Biology of Type IV Secretion Systems (p. 271)
Conclusion (p. 273)
Selected Readings (p. 273)
Chapter 15 Induction of Apoptosis by Microbial Pathogens (p. 275)
Apoptosis Is Genetically Programmed (p. 276)
Triggering of Apoptosis (p. 277)
Signal Transduction of a Cell Death Signal (p. 277)
Apoptosis and the Cell Cycle (p. 278)
Effector Molecules of Apoptosis (p. 278)
Caspases (p. 278)
Bcl-2 Family (p. 279)
Apoptosis in Diseases (p. 280)
Induction of Apoptosis by Microorganisms (p. 281)
Activation of Host Cell Receptors That Signal for Apoptosis (p. 281)
Induction of Second Messengers (p. 282)
Regulation of Caspase Activity (p. 283)
Inhibition of Apoptosis via Bcl-2 (p. 285)
Inhibition of Protein Synthesis (p. 286)
Disruption of the Cytoplasmic Membrane (p. 288)
Unknown Mechanisms (p. 289)
Selected Readings (p. 290)
Chapter 16 Interaction of Pathogens with the Innate and Adaptive Immune System (p. 291)
Innate and Adaptive Immunity (p. 291)
Innate Response (p. 292)
Macrophage Response--the Activated Macrophage (p. 293)
Interactions Involving Neutrophils (p. 297)
Interaction Involving the NK-Cell Response (p. 298)
Macrophage-NK-Cell Interaction: Lessons from Listeriosis (p. 299)
Symbiosis between the Innate Cellular System and the T-Cell Response--the MHC System (p. 301)
APC-T-Cell Interaction (p. 307)
Interactions with Adhesion Molecules (p. 307)
Interaction of CD40 with CD40L (p. 307)
Pairing of B7-1/B7-2 with CD28/CTLA-4 (p. 308)
Role of Cytokines (p. 308)
Apoptosis of Lymphocytes (p. 310)
Selected Readings (p. 310)
Chapter 17 Microscopy (p. 313)
Light Microscopy (p. 314)
Phase-Contrast, Differential Interference Contrast (Nomarski Optics), and Video Microscopy (p. 314)
Fluorescence Microscopy (p. 315)
Electron Microscopy (p. 318)
Basic Conventional Electron Microscopy (p. 318)
Methods To Study Intersection with the Endocytic Pathway (p. 319)
Immunoelectron Microscopy (p. 327)
Conclusion (p. 331)
Selected Readings (p. 332)
Chapter 18 Promising New Tools for Virulence Gene Discovery (p. 333)
Identifying Candidate Virulence Genes by Mutation (p. 334)
Enrichment Strategies (p. 334)
Signature-Tagged Mutagenesis (p. 334)
Identifying Candidate Virulence Genes by Differential Expression (p. 336)
Differential RNA Display (p. 336)
Promoter Traps (p. 338)
In Vivo Expression Technology (p. 339)
Differential Fluorescence Induction (p. 341)
Proteomics (p. 343)
Conclusion (p. 344)
Selected Readings (p. 345)
About the Contributors (p. 347)
Index (p. 353)