High borate glasses for the controlled release of therapeutic metal ions / Kathleen O'Connell.
By: O'Connell, Kathleen [author.].
Material type:
BookSeries: Ph.D. - Biological Sciences.Publisher: Cork : Cork Institute of Technology, 2016Description: ix, 167 pages : color graphs, illustrations, photographs, tables ; 30 cm.Content type: text Media type: unmediated Carrier type: volumeSubject(s): Biomedical materials
| Bioactive glasses | Biocompatibility | Metal ions | Metals in medicine | Bone substitutes | Bone regeneration | Biomedical engineeringDDC classification: THESES PRESS Dissertation note: Thesis (Ph.D) - Cork Institute of Technology, 2016. Summary: Within the biomaterial community significant effort has been directed towards engineering materials that induce precise host responses, which are tailored to specific applications. However, this has also seen an increase in the complexity of some biomaterials, which is being increasingly criticised within the literature, as it is attributed to hindering their clinical utility. In this context the release of therapeutic metal ions from glass-based biomaterials have been shown to promote hard tissue repair and regeneration through angiogenesis and osteogenesis processes. Within this thesis project two separate quaternary high borate glass systems were prepared containing the therapeutic metal ions strontium and gallium. Within study one and two the composition-structure-property relationships of each glass system were evaluated based on the increasing substitution of La₂O₃ or Ga₂O₃ for Na₂O. The ion increase capabilities were evaluated after extraction at 37°C in a shaking water bath (2Hz, longitudinal movement). Increasing substitutions of La₂O₃:Na₂O did not appear to dramatically alter the structure of the glass, specifically boron speciation, however the hydrolytic stability of the glasses was increased, which in turn significantly affected ion release. The increasing substitution of Ga₂O₃:Na₂O had a profound effect on the glass structure and boron speciation; linear increases in the relative concentration of hydrolysable BO₃ units and linear decreases in the relative concentration of more hydrolytically stable BO₄ structural units was observed. Irrespective of this, at {601}6:4 Ga₂O₃:Na₂O ratio, network stabilization appeared to occur, with decreases in ion release observed. Within study three (sub-chronic pilot study) a rabbit long-bone model was utilized to explore the safety and efficacy of LB102 (i.e. from the strontium release lanthanum containing high-borate glass series) for bone regeneration. Histopathological examination revealed that LB102 demonstrated osteoconductive and osseointegrative properties with greater new bone being formed within and surrounding LB102 particles, when compared to the untreated control. These studies demonstrated the possible utility of high borate glasses to act as controllable degradable materials for the delivery of therapeutic metal ions, strontium and gallium - (author's abstract).
| Item type | Current library | Call number | Copy number | Status | Date due | Barcode | Item holds |
|---|---|---|---|---|---|---|---|
| Reference | MTU Bishopstown Library Thesis | THESES PRESS (Browse shelf(Opens below)) | 1 | Reference | 00179909 |
Thesis (Ph.D) - Cork Institute of Technology, 2016.
Bibliography: (pages 146-166).
Within the biomaterial community significant effort has been directed towards engineering materials that induce precise host responses, which are tailored to specific applications. However, this has also seen an increase in the complexity of some biomaterials, which is being increasingly criticised within the literature, as it is attributed to hindering their clinical utility. In this context the release of therapeutic metal ions from glass-based biomaterials have been shown to promote hard tissue repair and regeneration through angiogenesis and osteogenesis processes. Within this thesis project two separate quaternary high borate glass systems were prepared containing the therapeutic metal ions strontium and gallium. Within study one and two the composition-structure-property relationships of each glass system were evaluated based on the increasing substitution of La₂O₃ or Ga₂O₃ for Na₂O. The ion increase capabilities were evaluated after extraction at 37°C in a shaking water bath (2Hz, longitudinal movement). Increasing substitutions of La₂O₃:Na₂O did not appear to dramatically alter the structure of the glass, specifically boron speciation, however the hydrolytic stability of the glasses was increased, which in turn significantly affected ion release. The increasing substitution of Ga₂O₃:Na₂O had a profound effect on the glass structure and boron speciation; linear increases in the relative concentration of hydrolysable BO₃ units and linear decreases in the relative concentration of more hydrolytically stable BO₄ structural units was observed. Irrespective of this, at {601}6:4 Ga₂O₃:Na₂O ratio, network stabilization appeared to occur, with decreases in ion release observed. Within study three (sub-chronic pilot study) a rabbit long-bone model was utilized to explore the safety and efficacy of LB102 (i.e. from the strontium release lanthanum containing high-borate glass series) for bone regeneration. Histopathological examination revealed that LB102 demonstrated osteoconductive and osseointegrative properties with greater new bone being formed within and surrounding LB102 particles, when compared to the untreated control. These studies demonstrated the possible utility of high borate glasses to act as controllable degradable materials for the delivery of therapeutic metal ions, strontium and gallium - (author's abstract).