MARC details
| 000 -LEADER |
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| fixed length control field |
nam a22 7a 4500 |
| 003 - CONTROL NUMBER IDENTIFIER |
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| control field |
IE-CoIT |
| 005 - DATE AND TIME OF LATEST TRANSACTION |
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| control field |
20180322113433.0 |
| 007 - PHYSICAL DESCRIPTION FIXED FIELD--GENERAL INFORMATION |
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| fixed length control field |
ta |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
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| fixed length control field |
180320s2017 ie ||||| |||| 00| 0|eng|| |
| 040 ## - CATALOGING SOURCE |
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| Original cataloging agency |
IE-CoIT |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
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| Classification number |
THESES PRESS |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
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| 9 (RLIN) |
123947 |
| Personal name |
Kennedy, Aideen |
| Relator term |
author |
| 245 12 - TITLE STATEMENT |
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| Title |
A diagnostic and control programme for Johne's Disease on Irish dairy farms / |
| Statement of responsibility, etc. |
Aideen Kennedy. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
Cork : |
| Name of producer, publisher, distributor, manufacturer |
Cork Institute of Technology, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2017. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
229 pages : |
| Other physical details |
illustrations (chiefly color) ; |
| Dimensions |
30 cm |
| 336 ## - CONTENT TYPE |
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| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
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| Media type term |
unmediated |
| Media type code |
n |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
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| Carrier type term |
volume |
| Carrier type code |
nc |
| Source |
rdacarrier |
| 490 #0 - SERIES STATEMENT |
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| Series statement |
Ph. D - Biological Sciences |
| 500 ## - GENERAL NOTE |
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| General note |
Johne's disease (JD) is an enteritis of ruminants with potential zoonotic implications. JD diagnosis ad control present difficulties give JDs prolonged subclinical nature. In order to improve JD control in Ireland, PhD aims included conducting a national survey documenting high-risk husbandry practices employed on Irish farms, thereby targeting areas for improved management. Furthermore as JD has been associated with on-farm economic losses internationally, this research programmed aimed to analyse production losses associated with testing JD ELISA positive on Irish dairy farms. A longitudinal study was also conducted to assess if successful JD control can be achieved using gold-standard protocols. Due to the prolonged nature of the disease, diagnosis of MAP is notoriously difficult. None of the available tests for MAP report perfect test sensitivity or specificity. A further complicating issue in Ireland, is the high level of bovine tuberculosis (bTB) testing that is conducted. Multiple investigations relating to bTB-testing and its relationship with MAP diagnostics were conducted. Across all investigations, 312 farms were recruited, samples were collected from 4500 cows, and 10000 test results were generated (ELISA, PCR, faecal culture). Irish farms engaged in high-risk management practices facilitating JD transmission, however, no significant associations were identified between JD ELISA positivity and production parameters. On-farm sero-prevalence was decreased by implementation of gold standard protocols. Eradication was not achieved, however, highlighting the long-term commitment required for effective JD control. Annual bTB testing was associated with an increased prevalence of JD ELISA positive results and indicates that sampling for the purposes of JD surveillance should be avoided for 71 days post- TB test administration. Antibody responses and interferon-y production were significantly increased post-b TB testing. As cell-mediated immunity is particularly important in the control of JD systemically, bTB testing may be contributing to the low levels of clinical JD in Ireland and warrants further investigation. This research programme has greatly contributed to our knowledge of JD in Ireland and improves understanding of practical measures necessary to interpret ELISA diagnostics and aid JD control - (Abstract) |
| 500 ## - GENERAL NOTE |
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| General note |
This Ph.D is a joint research project between Teagasc Moorepark and Cork Institute of Technology. |
| 502 ## - DISSERTATION NOTE |
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| Dissertation note |
Thesis |
| Degree type |
|
| Name of granting institution |
Cork Institute of Technology, |
| Year degree granted |
2017. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
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| Bibliography, etc. note |
Bibliography: (pages 203-229) |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| 9 (RLIN) |
93633 |
| Topical term or geographic name entry element |
Paratuberculosis |
| General subdivision |
Diagnosis |
| Geographic subdivision |
Ireland |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| 9 (RLIN) |
93633 |
| Topical term or geographic name entry element |
Paratuberculosis |
| General subdivision |
Prevention and control. |
| Geographic subdivision |
Ireland |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| 9 (RLIN) |
93631 |
| Topical term or geographic name entry element |
Mycobacterium avium paratuberculosis |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| 9 (RLIN) |
36972 |
| Topical term or geographic name entry element |
Enzyme-linked immunosorbent assay |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| 9 (RLIN) |
36051 |
| Topical term or geographic name entry element |
Dairy farming |
| General subdivision |
Management |
| Geographic subdivision |
Ireland |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Source of classification or shelving scheme |
Dewey Decimal Classification |