MARC details
| 000 -LEADER |
|---|
| fixed length control field |
02771nam a2200289 a 4500 |
| 008 - FIXED-LENGTH DATA ELEMENTS--GENERAL INFORMATION |
|---|
| fixed length control field |
2016 |
| 082 04 - DEWEY DECIMAL CLASSIFICATION NUMBER |
|---|
| Classification number |
THESES PRESS |
| 100 1# - MAIN ENTRY--PERSONAL NAME |
|---|
| Personal name |
Feeney, Audrey, |
| Relator term |
author. |
| 245 10 - TITLE STATEMENT |
|---|
| Title |
Identification of the molecular mechanisms governing the osmotolerance of the emerging gastrointestinal pathogen Cronobacter sakazakii / |
| Statement of responsibility, etc. |
Audrey Feeney. |
| 264 #1 - PRODUCTION, PUBLICATION, DISTRIBUTION, MANUFACTURE, AND COPYRIGHT NOTICE |
|---|
| Place of production, publication, distribution, manufacture |
Cork : |
| Name of producer, publisher, distributor, manufacturer |
Cork Institute of Technology, |
| Date of production, publication, distribution, manufacture, or copyright notice |
2015. |
| 300 ## - PHYSICAL DESCRIPTION |
|---|
| Extent |
156 pages : |
| Other physical details |
illustrations (some color), tables ; |
| Dimensions |
30 cm |
| 336 ## - CONTENT TYPE |
|---|
| Content type term |
text |
| Content type code |
txt |
| Source |
rdacontent |
| 337 ## - MEDIA TYPE |
|---|
| Media type term |
unmediated |
| Media type code |
n |
| Source |
rdamedia |
| 338 ## - CARRIER TYPE |
|---|
| Carrier type term |
volume |
| Carrier type code |
nc |
| Source |
rdacarrier |
| 490 0# - SERIES STATEMENT |
|---|
| Series statement |
Ph.D. - Biological Sciences |
| 502 ## - DISSERTATION NOTE |
|---|
| Dissertation note |
Thesis (Ph.D.) - Cork Institute of Technology, 2015. |
| 504 ## - BIBLIOGRAPHY, ETC. NOTE |
|---|
| Bibliography, etc. note |
Bibliography: p. 140-155. |
| 520 ## - SUMMARY, ETC. |
|---|
| Summary, etc. |
Cronobacter sakazakii is an organism which has been associated with severe life threatening diseases in infants and neonates. Mortality rates of up to 80% have been recorded in infants infected with Cronobacter sakazakii. Infants often suffer from septicaemia, necrotising enterocolitis and meningitis as a result of infection. A characteristic feature of the opportunistic foodborne pathogen Cronobacter sakazakii is its ability to survive in extremely arid environments such as powered infant formula, making it a dangerous opportunistic pathogen of neonates. Herein, we provide a brief overview of the pathogen, clinical manifestations, environmental reservoirs and our current understanding of stress response mechanisms and virulence factors which allow it to cause disease. The work presented in this thesis represents a significant contribution to the field of C. sakazakii osmotolerence research. In 2010, when this research began, the first C. sakazkaii genome was sequenced and it marked the beginning of the elucidation of the survival of this neonatal pathogen in PIF (powdered infant formula) and the mechanisms that facilitate the survival of the organism as it navigates the varying osmolality of the infant gastrointestinal tract. While this thesis has identified and characterised the osmotolerance loci of C. sakazakii, we recognise that the story is by no means complete. The identification of multiple ProP homologues on the C. sakazakii genome is a unique feature, coupled with the structural degeneracy between these compatible solute transport systems. - (Author's abstract) |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Enterobacter sakazakii. |
| 9 (RLIN) |
107285 |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Pathogenic microorganisms |
| General subdivision |
Analysis. |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Genomics. |
| 9 (RLIN) |
46112 |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Virulence (Microbiology) |
| 9 (RLIN) |
43766 |
| 650 #0 - SUBJECT ADDED ENTRY--TOPICAL TERM |
|---|
| Topical term or geographic name entry element |
Infant formulas |
| General subdivision |
Contamination. |
| 9 (RLIN) |
118273 |
| 907 ## - LOCAL DATA ELEMENT G, LDG (RLIN) |
|---|
| a |
.b1119263x |
| b |
160421 |
| c |
160420 |
| 942 ## - ADDED ENTRY ELEMENTS (KOHA) |
|---|
| Suppress in OPAC |
0 |
| 998 ## - LOCAL CONTROL INFORMATION (RLIN) |
|---|
| a |
c |
| Operator's initials, OID (RLIN) |
160420 |
| Cataloger's initials, CIN (RLIN) |
m |
| First Date, FD (RLIN) |
a |
| Local |
- |
| -- |
eng |
| -- |
ie |
| h |
0 |